You are here: Home

BMB Symposium

Main Content

Xenobiotic Receptors: Physiological Regulators and Mediators of Toxicity

Registration Is Now Open!

Early Bird Discount Available.

 

Please Check For Program Schedule Updates on the
Program Schedule page.

 

Hued Hepatocytes

Xenobiotic Receptors include members of the nuclear and soluble transcription factor superfamilies that serve as ‘xenosensors’ - chemical signal detectors and gene expression modulators that filter chemical  signals arising from a diverse array of environmental and endogenous substances. Upon activation, these receptors function to regulate numerous physiological processes ranging from the metabolism of steroids, pharmaceuticals and carcinogens, and in the control of critical lipid, cholesterol, energy and inflammatory pathways.

The 31st Penn State Summer Symposium in Molecular Biology will bring together preeminent scientists to focus on the most recent advances in Xenobiotic Receptor research that underlie their biological modes of action, and assess the impact of these processes on human health, chemical disposition and toxicity. Special emphasis will include focus on the receptors -  CAR/PXR (constitutive androstane and pregnane X receptors), the PPARs (peroxisome proliferator activated receptors), AhR (aryl hydrocarbon receptor) and highlight technological advances in comprehensive pathway analysis of these biological effectors.

The conference will be held at the upscale Nittany Lion Inn at Penn State University and is certain to be of broad interest to scientists engaged in all fields of basic research as well as those engaged as pharmaceutical and chemical industry scientists and government regulators.

 

Confirmed Speakers

Plenary

Gordon Hager, National Cancer Institute, NIH
Transcription Dynamics, Chromatin Transitions, and the Mechanisms of Regulatory Element Function

Keynote

Donald P. McDonnell, Duke University Medical School
Incorporating Our Evolving Understanding of Nuclear Receptor Action Into Mechanism-Based Screens for Endocrine Disrupters

 

CAR/PXR Session


H. Eric Xu, VARI/SIMM Research Center
Structural Biology of Xenobiotics Receptor CAR and Other Nuclear Receptors

Hongbing Wang, University of Maryland
In Vitro Identification of Novel CAR Activators: Integration of Computational and Biological Approaches

Curt Omiecinski, Penn State University
Natural Splice Variation in Human CAR Specifies Receptors With Unique Biological Properties

Reina Bendayan, University of Toronto
Regulation of Drug Transporters by Nuclear Receptors in the Brain

Sridhar Mani, Albert Einstein College of Medicine
Role of PXR in Malignancy

Wen Xie, University of Pittsburgh
The Endobiotic Function of CAR and PXR in Energy Metabolism

 

PPAR Session

Christopher K. Glass, University of California, San Diego
Genome-Wide Approaches to Understanding Nuclear Receptor Function

Frank Gonzalez, National Cancer Institute, NIH
Role of PPARa in Chemical Toxicity and Carcinogenesis

Patrick R. Griffin, The Scripps Research Institute
Mechanism of Action of Novel Insulin Sensitizers

Rolf Müller, Philipps University, Germany
PPARβ/δ, A Modulator of Cytokine Signaling and Tumorigenesis

Jeff Peters, Penn State University
Peroxisome Proliferator-Activated Receptor-β/δ-Dependent Regulation of Cancer

Bart Staels, University of Lille Nord de France
PPARS as Therapeutic Targets for Metabolic and Cardiovascular Disorders


Ah Receptor Session

Gary H. Perdew, Penn State University
Development and Therapeutic Potential of Selective Ah Receptor Modulators

Michael P. Cooke, Genomics Institute of the Novartis Research Foundation
Control of Human Hematopoietic Stem Cell Self-Renewal and Differentiation by the Aryl Hydrocarbon Receptor

Charlotte Esser, Institut für Umweltmedizinische Forschung (IUF), Germany
AhR and the Immune Cells of Barrier Organs

Agneta Rannug, Karolinska Institute, Sweden
Biological Properties of the High Affinity Endogenous Aryl Hydrocarbon Receptor Ligand FICZ

Christopher Bradfield, University of Wisconsin
Dioxin, Clocks and Oxygen

Stephen Safe, Texas A & M University
The Aryl Hydrocarbon Receptor as a Drug Target for Treating Advanced Breast Cancer


Applications of Xenobiotic Receptor Technology Session

Craig E. Thomas, Eli Lilly and Company
Early Safety Assessment - When Chemistry Meets Biology

Richard Judson, National Center for Computational Toxicology
Nuclear Receptor Activity Across Chemical Classes: Comparing ER and AhR Activity Trends Between Environmental Chemicals and Pharmaceuticals and Reference Compounds

J. Craig Rowlands, The Dow Chemical Company
The AH Receptor: Species Studies, Mode-of-Action, and Implication for Human Risk Assessment

Stephen Ferguson, Life Technologies, Inc.
Cryopreserved HepaRG Cells™ as Alternatives to Primary Human Hepatocytes for Modeling Receptor Activation Phenotypes

Jack Vanden Heuvel, Penn State University
Nuclear Receptors as Nutritional Targets: Implications For Prevention and Treatment of Metabolic Syndrome

 


 

 

Please visit our Symposium Sponsors

 

News:

Congratulations are in order to Penn State Scientists receive "Board of Publications Award for the Best Paper in Toxicological Sciences" at the Society of Toxicology Awards Ceremony on Sunday, March 11, 2012 for their paper entitled:

Selective Phthalate Activation of Naturally Occurring Human Constitutive Androstane Receptor Splice Variants and the Pregnane X Receptor

 

 

Image: "Hued Hepatocytes" by Elizabeth Iannone, M.D.

Used by permission


Document Actions

Footer