You are here: Home

BMB Symposium

Main Content

Xenobiotic Receptors: Physiological Regulators and Mediators of Toxicity

Registration Is Now Open!

 

Hued Hepatocytes

Xenobiotic Receptors include members of the nuclear and soluble transcription factor superfamilies that serve as ‘xenosensors’ - chemical signal detectors and gene expression modulators that filter chemical  signals arising from a diverse array of environmental and endogenous substances. Upon activation, these receptors function to regulate numerous physiological processes ranging from the metabolism of steroids, pharmaceuticals and carcinogens, and in the control of critical lipid, cholesterol, energy and inflammatory pathways.

The 31st Penn State Summer Symposium in Molecular Biology will bring together preeminent scientists to focus on the most recent advances in Xenobiotic Receptor research that underlie their biological modes of action, and assess the impact of these processes on human health, chemical disposition and toxicity. Special emphasis will include focus on the receptors -  CAR/PXR (constitutive androstane and pregnane X receptors), the PPARs (peroxisome proliferator activated receptors), AhR (aryl hydrocarbon receptor) and highlight technological advances in comprehensive pathway analysis of these biological effectors.

The conference will be held at the upscale Nittany Lion Inn at Penn State University and is certain to be of broad interest to scientists engaged in all fields of basic research as well as those engaged as pharmaceutical and chemical industry scientists and government regulators.

 

Confirmed Speakers

Plenary

Gordon Hager, National Cancer Institute, NIH

Keynote

Donald P. McDonnell, Duke University Medical School

PPAR Session

Christopher K. Glass, University of California, San Diego

Frank Gonzalez, National Cancer Institute, NIH

Patrick R. Griffin, The Scripps Research Institute

Jeff Peters, Penn State University

Rolf Müller, Philipps University, Germany

Bart Staels, University of Lille Nord de France

Ah Receptor Session

Christopher Bradfield, University of Wisconsin

Michael P. Cooke, Genomics Institute of the Novartis Research Foundation

Charlotte Esser, Institut für Umweltmedizinische Forschung (IUF), Germany

Gary H. Perdew, Penn State University

Agneta Rannug, Karolinska Institute, Sweden

Stephen Safe, Texas A & M University

CAR/PXR Session

Reina Bendayan, University of Toronto

Sridhar Mani, Albert Einstein College of Medicine

Curt Omiecinski, Penn State University

Hongbing Wang, University of Maryland

Wen Xie, University of Pittsburgh

H. Eric Xu, VARI/SIMM Research Center

Applications of Xenobiotic Receptor Technology Session

Keith Houck, National Center for Computational Toxicology

J. Craig Rowlands, The Dow Chemical Company

Craig E. Thomas, Eli Lilly and Company

Jack Vanden Heuvel, Penn State University

 


*Titles for each speaker will be available in the near future. Please check back!

 

 

Please visit our Symposium Sponsors

 

 

Image: "Hued Hepatocytes" by Elizabeth Iannone, M.D.

Used by permission


Document Actions

Footer