"Xenobiotic Receptors
in Toxicology and Carcinogenesis"

July 31 – August 3, 2002

Program Schedule

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Registration
Wednesday, July 31, 2002 - 4-6 p.m.
HUB-Robeson Center, Heritage Hall

Reception
Wednesday, July 31, 2002 - 5-7 p.m.
HUB-Robeson Center, Heritage Hall

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Final Registration

Thursday, August 1, 2002 - 8:00 a.m. - 10:00 a.m.
HUB-Robeson Center, Auditorium

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Welcome Address
Thursday, August 1, 2002 - 8:00 a.m.
HUB-Robeson Center, Auditorium

Jack Vanden Heuvel (Penn State)
"Xenobiotic receptors in toxicology and carcinogenesis"

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Session I
Thursday, August 1, 2002 - 8:30 a.m. - 12:00 p.m.

"Peroxisome Proliferator-activated Receptor"
HUB-Robeson Center, Auditorium

Chair: Jeff Peters (Penn State)

Ray DuBois (Vanderbilt) - PPARs and colorectal carcinogenesis

Bruce Spiegelman (Harvard) - Transcriptional basis of energy and glucose metabolism: Biological control at the coactivator level

Walter Wahli - Diverse functions of PPAR beta

Frank Gonzalez (NIH) - PPARs in toxicology and carcinogenesis

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Poster Session
Thursday, August 1, 2002 - 1:30 p.m. - 4:30 p.m.
HUB-Robeson Center, Alumni Hall

Chair: Curt Omiecinski (U. Washington)

(faculty, post-doctorates and students selected from submitted abstracts)

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Keynote Address
Thursday, August 1, 2002 - 7:00 p.m.
HUB-Robeson Center, Auditorium

Ron Evans (Salk Institute)
"Nuclear Receptors and the Exotics of Xenobiotics"

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Session II
Friday, August 2, 2002 - 8:30 a.m. - 12:00 p.m.

"PXR/CAR"
HUB-Robeson Center, Auditorium

Chair: Channa Reddy (Penn State)

Steve Kliewer (Southwestern) - Regulation of xenobiotic and bile acid metabolism by PXR

Masahiko Negishi (NIH) - Phenobarbitol induction and nuclear receptor CAR

David Moore (BAYLOR) - Metabolic regulation by the nuclear receptor CAR

Curt Omiecinski (U. Washington) - Structural and functional variation in the human constitutive androstane receptor (CAR)

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Industrial Exhibits
Friday, August 2, 2002 - 10:00 a.m. - 4:00 p.m.
HUB-Robeson Center, Alumni Hall

(Lunch provided by industrial exhibitors)

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Session III
Friday, August 2, 2002 - 1:30 p.m. - 5:00 p.m.

"Aryl Hydrocarbon Receptor"
HUB-Robeson Center, Auditorium

Chair: Craig Marcus (U. of New Mexico)

Chris Bradfield (U. Wisconsin) - Dioxins, clocks and oxygen: The Ah receptor as prototype

Gary Perdew (Penn State) - Role of chaperones in modulating Ah receptor activity

Oliver Hankinson (UCLA) - Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor/arl hydrocarbon receptor nuclear translocator (AHR/ARNT) dimer

Mike Denison (UC Davis) - Activation of the Ah receptor by structurally diverse ligands

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Hub Lawn Barbecue
Friday, August 2, 2002 - 5:00 p.m. - 8:00 p.m.
HUB-Robeson Center, South Lawn

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Session IV
Saturday, August 3, 2002 - 8:30 a.m. - 12:00 p.m.

"Estrogen Receptor"
HUB-Robeson Center, Auditorium

Chair: Blake Peterson (Penn State)

Geoffrey L. Greene (U.Chicago) - Structural aspects of ligand discrimination between ERalpha and ERbeta

Vincent Giguere (McGill U.) - The ERR in the estrogen pathway

Steve Safe (Texas A&M) - Mechanism of estrogen receptor/sp1-mediated activation of genes in breast cancer cells

Ken Korach (NIH) - Determining the differential functions of ER alpha and beta using the ERKO mouse models